Two Pore Guys Receives $2.8M Grant to Develop Sensitive, Low-Cost Molecular Diagnostic Tests for Tuberculosis
(Source: Business Wire)
November 27, 2018 — Santa Cruz, CA
Goal of Bill & Melinda Gates Foundation Grant Is to Improve TB Care in Resource-Poor Settings
Two Pore Guys, Inc. (2PG) today announced that the company has received a $2.8 million grant from the Bill & Melinda Gates Foundation to develop sensitive, low-cost molecular diagnostic tests for tuberculosis (TB) using its solid-state nanopore technology. The 18-month grant will fund proof-of-concept work to determine if 2PG technology could provide an easy-to-use, sensitive and low-cost point-of-care device that would be compatible with automated, wireless reporting for resource-poor settings.
TB is one of the top 10 causes of death worldwide, and the leading cause from a single infectious agent. Millions of people continue to fall sick with TB each year. WHO estimates 10 million people developed TB last year worldwide.
The WHO 2018 Global TB Report, released in September, calls for an unprecedented mobilization of national and international commitments to meet the global target of ending TB by 2030. Underdiagnosis of TB is a major challenge: only about 6.4 million of the 10 million people who contracted TB in 2017 were officially recorded by national reporting systems, leaving 3.6 million people undiagnosed or detected but not reported. Late detection of Mycobacterium tuberculosis (MTB), the infectious organism that causes TB, increases the risk of transmission, delays treatment, and burdens the healthcare system. Lack of affordable, sensitive and rapid detection of MTB is a major hurdle in low- and middle-income countries. Implementing a low-cost, sensitive and portable molecular diagnostic test is expected to save thousands of dollars per patient.
“Our point-of-care technology platform offers tremendous value to address medical testing needs in resource-limited areas,” said William Dunbar, Co-founder and interim CEO of Two Pore Guys. “We are grateful to the Bill & Melinda Gates Foundation for this support and for their enthusiasm about the promise of our technology. We hope to make a difference in the lives of millions of people around the world who need better access to affordable TB care.”
About the 2PG Technology
Unlike biological nanopores used in some DNA sequencing technologies, 2PG’s devices employ silicon nanopore chips, which are robust sensors that examine a wide range of individual analytes with high sensitivity. Additionally, 2PG workflows can support multiplexed and multi-modal assays, i.e., to test for DNA/RNA and analyte/protein from a single sample source. 2PG’s patented methods also permit genotyping, e.g., for detecting drug resistance. For more information, including demonstration videos, please visit www.twoporeguys.com.
About Two Pore Guys, Inc.
2PG is developing a single-molecule sensing platform with the accuracy and sensitivity of reference lab equipment and sample-in, results-out capability. The core technology includes solid-state, nanopore-based sensors that can detect nucleic acids and proteins and other analytes in human, animal, agriculture, and environmental samples. The easy-to-use platform in development is designed to sync with a smartphone or computer for further analysis and data sharing, including integration with electronic health records. The company is based in Santa Cruz, Calif. For more information, visit www.twoporeguys.com.
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